登录  注册
肿瘤学学术中心首页 > 期刊 > 中国作者重要发表

肿瘤学学术中心

胰腺癌侵神经现象新见解:不仅仅是疼痛

New insights into perineural invasion of pancreatic cancer: More than pain

来源:Scopus 发布时间:2016-6-12
作者:Liang D, Shi S, Xu J, Zhang B, Qin Y, Ji S, Xu W, Liu J, Liu L, Liu C, Long J, Ni Q, Yu X
机构: 中国上海,复旦大学胰腺肿瘤研究所,复旦大学上海医学院肿瘤系,复旦大学上海市肿瘤医院胰腺及肝胆外科
期刊: Biochim Biophys Acta2016年4月2期1685卷

Pancreatic cancer is one of the most malignant human tumors. Perineural invasion, whereby a cancer cell invades the perineural spaces surrounding nerves, is acknowledged as a gradual contributor to cancer aggressiveness. Furthermore, perineural invasion is considered one of the root causes of the recurrence and metastasis observed after pancreatic resection, and it is also an independent predictor of prognosis. Advanced research has demonstrated that the neural microenvironment is closely associated with perineural invasion in pancreatic cancer. Therapy targeting the molecular mechanism of perineural invasion may enable the durable clinical treatment of this formidable disease. This review provides an overview of the present status of perineural invasion, the relevant molecular mechanisms of perineural invasion, pain and hyperglycemia associated with perineural invasion in pancreatic cancer, and the targeted therapeutics based on these studies. © 2016 Elsevier B.V.

通讯作者:Department of Pancreatic and Hepatobiliary Surgery, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Pancreatic Cancer Institute, Fudan University, Shanghai, China.
顶一下(0

发表评论

学科影响因子排名more

 会议回顾 more

  • 【专题】2015年美国临床肿瘤大会...

  • 多模式防治 改善肿瘤患者生存

  • 第13届St. Gallen国际乳...

 热门病例 more

 热门指南  more

Elsevier中国网站
爱唯医学网
爱思唯尔科技部
NursingChina
柳叶刀中文版
大通医疗决策
医大爱思唯尔
Elsevier医学数据库
CK
Journal Consult
Procedures_CONSULT
ClinicalPharmacologyLogo
3D Interact Anatomy
Mosby’s Nursing Consult
NursingChina
Science Direct